منابع مشابه
Galectin-1 Pulls the Strings on VEGFR2
Anti-vascular endothelial growth factor (VEGF) cancer immunotherapy targets angiogenesis but development of resistance in patients is common. In this issue of Cell, Croci et al. identify a complex set of mechanisms by which galectin-1 prolongs cell-surface retention of VEGF receptor 2 (VEGFR2) and stimulates VEGF-independent tumor angiogenesis.
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Tyrosine kinase inhibitors (TKIs) targeting the BCRABL1 kinase have revolutionized the treatment strategy for Philadelphia chromosome-positive (Ph+) chronic myelogenous leukemia (CML) and acute lymphoblastic leukemia (ALL). Among the TKIs, dasatinib is distinctive in that it inhibits a broad spectrum of tyrosine kinases, including key regulators of immune responses [1]. In agreement with this p...
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AIM Accumulating evidence suggests that extracellular galectin-1 and galectin-3 promote angiogenesis. Increased expression of galectin-1 and/or galectin-3 has been reported to be associated with tumour progression. Thus, it is critical to identify their influence on angiogenesis. METHODS We examined the individual and combined effects of galectin-1 and galectin-3 on endothelial cell (EC) grow...
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It seems a foregone conclusion that repositories for reusable learning objects (RLOs), based on common standards and supported by suitable search facilities, will foster a global economic market in the production of RLOs. Actual reuse will support producers of high-quality RLOs, and other producers will be unable to compete, i.e. competition within the market will implicitly define the qualitie...
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ژورنال
عنوان ژورنال: Cell
سال: 2014
ISSN: 0092-8674
DOI: 10.1016/j.cell.2014.01.059